Some weeks back, George's HRT prescription was changed from 200mg/ml to 100mg/ml, basically doubling the dose to achieve the same amount of a more diluted testosterone shot. It wasn't ideal, but it was the option available to him at the time. But in the intervening weeks, he has been more irritable, and irritability can be a side effect of HRT. Is the testosterone making him cranky, or is it just the unrelenting nonsense?
The podcast we referenced is a Hidden Brain episode called "All The World's A Stage - Including The Doctor's Office", and it can be found at https://www.npr.org/2019/04/29/718227789/all-the-worlds-a-stage-including-the-doctor-s-office.
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